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Possible Relationship to Leukoderma Acquisitum Centrifugum (Halo Nevus)

JAMES H. GRAHAM, MD; NORMAN A. FOGEL, MD; CARROLL F. BURGOON, JR., MD

Arch Dermatol. 1963;88(3):313-319.

Abstract
A two-year-old Negro patient with multiple nonpigmented nevi is reported. Our histopathological and histochemical studies indicate an active melanin-producing system within the nevus cells. Hypopigmentation and failure of the lesions to repigment may be due to a defect in melanogenesis or faulty transfer of melanin to epidermal cells. Rapid dropping off of pigment into the corium may be another contributory factor.

Author Affiliations
PHILADELPHIA

From The Skin and Cancer Hospital of Philadelphia, Department of Dermatology, Temple University School of Medicine.

Footnotes
This investigation was supported in part by research grant No. 4275 (C2S1) from the National Cancer Institute, and research training grant No. 2A-5289 (C1) from The National Institute of Arthritis and Metabolic Diseases, Public Health Service, Bethesda 14, Md.

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ABSTRACT