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A Histochemical and Electron Microscope Study

ALVIN S. ZELICKSON, MD

Arch Dermatol. 1963;88(5):497-509.

Abstract
Study of cultured fibroblasts on consecutive days of growth demonstrated them to be polymorphic cells capable of many forms and functions. On the fourth day of growth there is the formation of a well-developed endoplasmic reticulum and a marked folding of the cell membrane. Subsequently, filaments form intracellularly and are later released from the cell through the folds in the cell membrane. Following this, the filaments line up laterally and longitudinally in the extracellular space, thus giving rise to the striated collagen fibers.

Author Affiliations
MINNEAPOLIS

From the Division of Dermatology, University of Minnesota Medical School.

Footnotes
This paper was awarded the First Prize in the Annual Essay Contest conducted by the American Dermatological Association Research and Educational Fund. Presented at the 83rd Annual Meeting of the American Dermatological Association, Inc., April 16-19, 1963.

Aided by research grant CA-05887 from the USPHS and by research grants M-388 and B-782 from the National Institute of Mental Health and the National Institute for Neurologic Diseases and Blindness, USPHS (administered by Dr. J. F. Hartmann).

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