
Quantitative Estimation of Keratin Production by the Epidermis
HERBERT GOLDSCHMIDT, MD;
ALBERT M. KLIGMAN, MD
Arch Dermatol. 1963;88(6):709-712.
Abstract
Scales have been collected from different protected areas of the body for periods of three to six weeks. Crude soft horn production was five to ten times higher on the scalp, forehead, and palms than elsewhere. The synthesis of keratin diminishes centrifugally from the scalp downwards and outwards (excepting the palms and soles).
The total production of crude soft horn per day for the entire skin surface is 0.5 to 1.0 gm. The nitrogen loss via skin shedding is thus trivial.
Author Affiliations
PHILDELPHIA
From the Department of Dermatology, University of Pennsylvania, School of Medicine.
Footnotes
This study was conducted under the sponsorship of the Commission on Cutaneous Diseases of the Armed Forces Epidemiological Board and was supported by The Surgeon General, Department of the Army.
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