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The Topical Action of 3-Methyl-4-Amino-N-Diethyl-Aniline-Monohydrochloride (CD-2) on the Skin

ERIK A. KNUDSEN, MD

Arch Dermatol. 1964;89(3):357-359.

Abstract
Twenty-nine randomly selected eczema patients were patch-tested for 48 hours with a 25% aqueous solution of CD-2. Two patients (one of whom also was found to be allergic to paraphenylenediamine) became sensitized to CD-2. Among seven patients with known paraphenylenediamine allergy, one was also allergic to CD-2. An additional three patients with lichenoid eruption after contact with CD-2 were tested with 1% aqueous solution of CD-2 for 48 hours, both on intact skin and on skin from which the horny layer had been removed. In none of the total of six patients allergic to CD-2 were any lichenoid changes produced by the testing.

In six patients with lichen planus, daily painting of the skin with 25% aqueous solution of CD-2 for up to four weeks resulted in no deterioration of the existing condition.

Author Affiliations
COPENHAGEN, DENMARK

From the Department of Skin and Venereal Diseases, University of Copenhagen Medical School, Rigshospitalet, Copenhagen, Denmark.

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