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ROBERT B. GREENBLATT, MD, CM; VIRENDRA B. MAHESH, PhD; LAMBROS C. RIGAS, MD; STANLEY T. SHAPIRO

Arch Dermatol. 1964;89(6):846-857.

Abstract
The biosynthesis, physiology, and pharmacology of progesterone and estrogen are briefly discussed.

A study on the absorption of estrogens by the skin when applied in the form of a cream containing 10,000 IU of estrogens and 5 mg progesterone per ounce was carried out on two sisters, aged 14 and 17, and a 35-year-old female with gonadal dysgenesis. It was concluded that the cream produced no significant local effects and the absorption was too minor to produce any systemic effect. More concentrated estrogen-progesterone cream containing 50,000 IU of estrogens and 25 mg of progesterone per ounce had significant local effects when applied to the vagina and vulvae of a 58-year-old woman with dyskeratotic lesions of the vulvae.

Author Affiliations
AUGUSTA, GA

Department of Endocrinology, Medical College of Georgia.

Footnotes
Presented at the Meeting of the American Academy of Dermatology, Chicago, Dec 3, 1963.

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