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Observations in 52 Patients With Syphilis

LT R. G. SABLAN, MC; LCDR W. C. BEST, MC

Arch Dermatol. 1964;90(3):293-295.

Abstract
The febrile response, as part of the Jarisch-Herxheimer reaction, was studied in 52 patients with proven primary and secondary syphilis treated with penicillin. Temperature elevation was noted as early as 1 hour and as late as 11 hours after the initial injection. The largest number (about 46%) occurred within three to five hours. Peak temperature elevation occurred most frequently six hours after onset of therapy. Fever ranged from 37.7 C (99.8 F) to 40.0C (104.0 F) and subsided in all cases within 18 hours.

Author Affiliations
USN; USN SAN DIEGO, CALIF

US Naval Hospital.

Footnotes
The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the view of the Navy Department, or the Naval Service at large.

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