This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

In the Serum of Patients With Acne Vulgaris, Using Bacterial Agglutination, Agar Gel Immunodiffusion, and Immunofluorescence Techniques

S. M. PUHVEL, PhD; M. BARFATANI, PhD; M. WARNICK, MD; T. H. STERNBERG, MD

Arch Dermatol. 1964;90(4):421-427.

Abstract
Sera from 22 patients with varying degrees of acne vulgaris were tested for antibody levels to Corynebacterium acnes using bacterial agglutination, agar gel immunodiffusion, and immunofluorescence techniques. The results indicated that patients with pustular and cystic acne had significantly higher levels of antibody to C acnes than did patients with mild comedopapular acne and persons with healthy skin. Sera from 18 patients with skin diseases other than acne were also tested, and in this group the antibody levels to C acnes were in the same range as those found in persons with healthy skin. The fact that antibody levels to C acnes are higher in persons with severe acne, may indicate that C acnes is etiologically involved in acne vulgaris. On the other hand, the rise of antibody levels to C acnes may be the result of nonspecific involvement of the organism in the acne lesion. Further investigations are presently being carried out to elucidate these possibilities.

Author Affiliations
LOS ANGELES

Department of Medicine, Division of Dermatology, Center for the Health Sciences, University of California.

Footnotes
This study was supported by United States Public Health Service grant No. 5 T1 Al 52-05, United States Public Health Service grant T1 AM 5265-04, and by the Dermatologic Research Foundation of California, Inc.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acne Vulgaris and Free Fatty Acids: A Review and Criticism
Voss
Arch Dermatol 1974;109:894-898.
ABSTRACT  

Corynebacterium Acnes: Presence of Complement Fixing Antibodies to Corynebacterium acnes in the Sera of Patients With Acne Vulgaris
PUHVEL et al.
Arch Dermatol 1966;93:364-366.
ABSTRACT  

Oral Tetracycline Treatment on Bacterial Flora in Acne Vulgaris
GOLTZ and KJARTANSSON
Arch Dermatol 1966;93:92-100.
ABSTRACT  

Levels of Antibody to Staphylococcus epidermidis in Patients With Acne Vulgaris
PUHVEL et al.
Arch Dermatol 1965;92:88-90.
ABSTRACT