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HERMANN PINKUS, MD

Arch Dermatol. 1965;91(1):24-37.

Abstract
Squamous cell carcinoma and basal cell epithelioma are not just two varieties of skin cancer; they belong to different classes of tumors, as was already pointed out by Lever in 1948. However, since 1948 it has become apparent that the essential difference is not point of origin or cause of tumor formation; rather, it is the differential biologic response of the adult skin to carcinogenic stimulation: development of independent epithelial cell strains in squamous cell carcinoma and adenocarcinoma, interdependent fibroepithelial proliferation in papillomas, benign adnexal tumors, and basal cell epithelioma.

Author Affiliations
DETROIT

From the Departments of Dermatology, Wayne State University School of Medicine and Detroit Receiving Hospital.

Footnotes
Modified from the Annual Howard Fox Memorial Lecture of the Section of Dermatology, New York Academy of Medicine, April 7, 1964.

Supported in part by research grant AM-07194 from the USPHS through the National Institutes of Health.

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