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The Seip-Lawrence Syndrome

WILLIAM B. REED, MD; ROBERT DEXTER, MD; CHARLES CORLEY, MD; CHARLES FISH, MD

Arch Dermatol. 1965;91(4):326-334.

Abstract
Three living patients with congenital lipodystrophic diabetes and an autopsied infant with leprechaunism have been discussed. Acanthosis nigricans, hirsutism, and generalized lipodystrophy are dermatological features of this multisystem disorder. Other features include increased growth before puberty, enlarged genitalia, diabetes without severe ketosis, hepatomegaly and occasional splenomegaly, enlarged ventricles of the brain, sometimes mental deficiency, large hands and feet, and occasionally congenital anomalies of the heart, bones, and kidneys. The condition is probably transmitted as an autosomal recessive trait.

Author Affiliations
BURBANK, CALIF; PORTERVILLE, CALIF; SONOMA, CALIF; COSTA MESA, CALIF

From the Porterville State Hospital (Dr. Dexter); the Sonoma State Hospital (Dr. Corley); and the Fairview State Hospital (Dr. Fish).

Footnotes
Accepted for publication Dec 21, 1964.

Reprint requests to 1013 W Olive Ave, Burbank, Calif 91524 (Dr. Reed).

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