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HARRY M. ROBINSON, JR., MD; JOAN RASKIN, MD

Arch Dermatol. 1965;91(4):372-376.

Abstract
Tolnaftate solution (0.5% and 1.0%) is effective in the treatment of superficial mycotic infections due to Trichophyton rubrum, T mentagrophytes, Epidermophyton floccosum, Microsporum canis, T tonsurans, and Malassezia furfur.

When the diagnosis of a mycotic infection is established from scrapings and cultures, relief from itching is produced by topical applications in from 24 to 72 hours.

Interdigital infections due to T rubrum, T mentagrophytes, and E floccosum are cleared in 7 to 21 days.

Tolnaftate solution was of no value in the treatment of Candida albicans infections, scalp and nail lesions.

In vitro, tolnaftate solution has antifungal activity against M gypseum, T rubrum, M canis, E floccosum, T tonsurans, M audouini, and T mentagrophytes, but not against Penicillium notatum, Aspergillus niger, or C albicans.

In vitro studies indicate that tolnaftate solution has fungicidal as well as fungistatic activity.

Author Affiliations
BALTIMORE

From the Division of Dermatology, Department of Medicine, University of Maryland School of Medicine.

Footnotes
Accepted for publication Nov 27, 1964.

Reprint requests to University of Maryland School Medicine, Baltimore, Md 21201 (Dr. Robinson).

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