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Do Treponemes Survive Adequate Treatment of Late Syphilis?
ANNE ROOF YOBS, MD;
SIDNEY OLANSKY, MD;
DONALD H. ROCKWELL, MD;
JOHN W. CLARK, JR.
Arch Dermatol. 1965;91(4):379-389.
Abstract
Nodes from 45 men who had been treated for syphilis in varying stages of the disease were studied. Five of these nodes were shown to contain treponeme-like forms, which in two cases proved to be virulent. Repeat node study after supervised treatment was completely negative in all five men. Possible reinfection and inadequacy of previous treatment undoubtedly are important factors in the original findings. Penicillin is the drug of choice in the treatment of syphilis. There is no evidence that Treponema pallidum survives in humans after adequate penicillin treatment.
Author Affiliations
ATLANTA, GA
From the Venereal Disease Research Laboratory, Communicable Disease Center, Public Health Service, Department of Health, Education, and Welfare. Chief, Medical Research, Venereal Disease Research Laboratory (Dr. Yobs); Professor of Medicine (Dermatology), Emory University School of Medicine (Dr. Olansky); Surgeon, USPHS(R), Medical Research, Venereal Disease Research Laboratory (Dr. Rockwell); Microbiologist, Medical Research, Venereal Disease Research Laboratory (J. W. Clark, Jr.).
Footnotes
Accepted for publication Nov 19, 1964.
Presented before meeting of American Dermatological Association, Maui, Hawaii, June 28-July 3, 1964.
Trade names are for identification only and do not represent an endorsement by the US Public Health Service.
Reprint requests to Atlanta, Ga 30322 (Dr. Yobs).
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