Physiologic Changes In Vitiligo
M. L. CHANCO-TURNER, MD;
AARON B. LERNER, MD
Arch Dermatol. 1965;91(4):390-396.
Abstract
We compared normal and vitiliginous areas and found: (a) surface temperature was increased; (b) sweat production was increased; (c) bleeding time was prolonged and the quantity of bleeding was increased.
In both normal and vitiliginous areas, responses to locally administered acetylcholine, epinephrine, and histamine were similar.
These resuts suggest that there is enhanced cholinergic activity in vitiliginous skin. This may be a direct effect of increased local acetylcholine concentration due either to increased secretion or delayed local clearing. On the other hand, this cholinergic activity may be due to relatively diminished local epinephrine and I-norepinephrine resulting from decreased secretion or a more rapid clearing of these sympathomimetic amines. The actual mechanism remains to be clarified.
Author Affiliations
NEW HAVEN, CONN
From the Section of Dermatology, Department of Medicine, Yale University School of Medicine. Clinical trainee of USPHS grant No. 2T1 AM 5264 (Dr. Lerner).
Footnotes
Accepted for publication Oct 29, 1964.
Reprint requests to Dr. Lerner.
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