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YUTAKA MISHIMA, MD, PhD

Arch Dermatol. 1965;91(5):519-557.

Abstract
The special cytoplasmic organelle, melanosome, formed in the Golgi region, is the site of melanin synthesis. Under electron microscopy, these melanosomes are found to assume distinct structural characteristics for various disease states such as melanoma, cellular nevi, blue nevus, nevus Ota, vitiligo, albinism, and others, providing diagnostic criteria for molecular pathology. In albino human and fish integument, melanization can be induced in vitro, using corticotropin or l-tyrosine. Electron histochemistry and radio-bioassay for tyrosinase can reveal its presence and subcellular localization in both of these tissues. The defect of albino fish appears to be a disturbed association of tyrosinase with the melanosome, while human albinism constitutes a different nature and may be the result of lack of free l-tyrosine molecules available to the melanosome, although some dermal inhibitary factors are also seen. Subcellular and cytochemical characteristics with reference to their origin are described.

Author Affiliations
DETROIT

From the Departments of Dermatology, Wayne State University School of Medicine, Detroit, and Veterans Administration Hospital, Dearborn, Mich.

Footnotes
Accepted for publication Dec 2, 1964.

Read before the 84th Annual Meeting of the American Dermatological Association, Inc., Sheraton-Maui, Kaanapali, Hawaii, June 28-July 2, 1964.

This paper was awarded the First Prize in the Annual Essay Contest of the American Dermatological Association.

Reprint requests to 1401 Rivard, Detroit, Mich 48207.

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