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The Effect of Stripping and Occlusion

ROBERT J. FELDMANN, MD; HOWARD I. MAIBACH, MD

Arch Dermatol. 1965;91(6):661-666.

Abstract
Between 0.2 and 1.0 per cent of hydrocortisone, applied to normal skin appears in the urine over a period of ten days. Stripping the skin doubles this amount and significantly alters the absorption rate curve. An occlusive dressing increases absorption ten-fold but does not basically alter the absorption rate curve. Evidence is presented suggesting that both the stratum corneum and the Malpighian/basal layers serve as skin barriers.

Author Affiliations
SAN FRANCISCO

From the Division of Dermatology, University of California, San Francisco Medical Center, San Francisco, Calif, (Dr. Feldmann and Dr. Maibach).

Footnotes
Accepted for publication Jan 15, 1965.

Reprint requests to the Division of Dermatology, University of California, San Francisco, Calif 94122 (Dr. Feldmann).

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