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K. STEPHENS TAYLOR, MD; FREDERICK D. MALKINSON, MD, DMD; CARL GAK, MD

Arch Dermatol. 1965;92(2):174-177.

Abstract
This study was undertaken to investigate the possible pituitary-adrenal suppressive effects of triamcinolone acetonide under occlusive dressings in six psoriatic patients. Forty-five grams of a cream containing 0.1% triamcinolone acetonide was applied daily to the psoriatic lesions of four patients and covered with an occlusive dressing. Two patients received daily applications of 45 gm of 0.01% triamcinolone acetonide cream and occlusive dressings. The four patients who received the 0.1% triamcinolone acetonide applications showed a marked decrease in the 24-hour urinary 17-hydroxycorticosteroids and no significant response to intravenous metyrapone testing. The two patients who were treated with 0.01% triamcinolone acetonide also showed a significant decrease in 24-hour urinary 17-hydroxycorticosteroids, but a partial response to metyrapone testing. Percutaneous absorption of as little as 1 to 2 mg of triamcinolone acetonide may affect pituitary-adrenal function.

Author Affiliations
CHICAGO

From the Section of Dermatology (Department of Medicine) and the Department of Medicine, University of Chicago.

Footnotes
Accepted for publication April 14, 1965.

Reprint requests to Section of Dermatology, Department of Medicine, University of Chicago 60637 (Dr. Malkinson).

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