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ERIK SKOG, MD

Arch Dermatol. 1965;92(3):276-280.

Abstract
p-Phenylenediamine (PPD) from 0.2 mg to 1.6 mg in water or in petrolatum was applied as a patch test to 501 patients with different dermatoses, asthma, hay fever, and venereal diseases.

Of these patients 10.6% reacted within the first five days indicating previous hypersensitivity and 14.4% between the sixth and the 16th day indicating the initiation of hypersensitivity to PPD by the patch application (flare-up).

The reactions within the first five days were not correlated with the amount of PPD in the tests, but a statisically significant correlation was found between flare-ups and amount, so that the larger the amount of PPD the higher the frequency of flare-ups.

About one half of both reactions occurred in patients with eczematous dermatitis.

Author Affiliations
STOCKHOLM

From the National Institute of Public Health, Stockholm, and the Department of Dermatology, Karolinska Sjukhuset.

Footnotes
Accepted for publication June 1, 1965.

Reprint requests to Department of Dermatology, Karolinska Sjukhuset, Stockholm 60, Sweden.

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