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A Manifestation of Generalized Elastolysis

ROBERT W. GOLTZ, MD; ANNE-MARIE HULT, MS; MACE GOLDFARB, MD; ROBERT J. GORLIN, DDS

Arch Dermatol. 1965;92(4):373-387.

Abstract
The condition known as cutis laxa has been reviewed and two examples occurring in brothers reported. One of these children died from complications of his disease and came to autopsy. Extensive histologic, ultramicroscopic, histochemical, and biochemical studies on skin and other organs demonstrated a defect of elastic fibers throughout the body. Review of the literature indicates similar widespread involvement in other cases of this disease. Therefore, the title generalized elastolysis is proposed to express, better than does cutis laxa, the extensive distribution in connective tissues of this rare but serious disease.

The occurrence of this syndrome in siblings and the evidence of parental consanguinity in several pedigrees strongly suggest an autosomal recessive inheritance.

Author Affiliations
MINNEAPOLIS

From the Division of Dermatology and the Division of Oral Pathology, University of Minnesota. Professor and Director of Dermatology, University of Colorado (Dr. Goltz); Assistant Scientist, Division of Dermatology, University of Minnesota (A. Hult); Medical Fellow, Department of Pediatrics (Dr. Goldfarb); and Professor and Chairman, Division of Oral Pathology (Dr. Gorlin).

Footnotes
Accepted for publication June 4, 1965.

Reprint requests to Division of Dermatology, University of Colorado Medical Center, Denver, Colo 80220 (Dr. Goltz).

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