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A Preliminary Report

MALCOLM C. SPENCER, MD

Arch Dermatol. 1965;92(6):688-689.

Abstract
A series of 43 patients, the majority with grade 3 or grade 4 acne received a total of 79 two-week courses of either chymotrypsin with trypsin (Chymoral) or placebo treatment combined with routine local therapy on a randomized, double-blind basis.

In this series, chymotrypsin with trypsin was significantly better (P<0.05) in improving the condition than was the placebo control.

Based on preliminary data, it would appear that a two-week course of chymotrypsin with trypsin treatment is a minimum in order to achieve successful results.

Author Affiliations
DANVILLE, ILL

From the Department of Dermatology, Northwestern University Medical School.

Footnotes
Accepted for publication July 29, 1965.

Reprint requests to 605 N Logan Ave, Danville, Ill 61833.

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