This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Dichotomy of Results Between Man and Laboratory Animal with 16, 17-Dihydroxyprogesterone Acetonide

SEYMOUR BRONSTEIN, MD; WILLIAM GRATER, MD; COLEMAN JACOBSON, MD; NORMAN ORENTREICH, MD; NORMAN APPLEZWEIG

Arch Dermatol. 1966;93(1):114-118.

Abstract
This non-corticoid steroid possesses potent local anti-inflammatory activity in animals. Study was therefore undertaken of its topical activity in humans. The negative results in man demonstrate a dichotomy in activity between species. However, in man, there was correlation between poor vaso-constrictor activity and lack of anti-inflammatory activity by this non-corticoid structure.

Author Affiliations
MORRIS PLAINS, NJ; DALLAS; NEW YORK

From the Division of Clinical Research, Warner-Lambert Research Institute, Morris Plains, NJ.

Footnotes
Accepted for publication Aug 31, 1965.

Reprint requests to May Institute for Medical Research, Jewish Hospital, Cincinnati, 45229 (Dr. Bronstein).

CiteULike    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter     What's this?