This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (84)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinicopathological and Histochemical Study

WAINE C. JOHNSON, MD; ELSON B. HELWIG, MD

Arch Dermatol. 1966;93(1):13-20.

Abstract
A study of 14 patients with focal mucinosis revealed the usual clinical features—a solitary, asymptomatic, flesh-colored to white papule or nodule. The pathologic changes consisted of fibroblastic proliferation in the corium, an increased production of hyaluronic acid by these fibroblasts and an associated decrease or absence of reticulum and collagen formation. Hyaluronic acid accumulates between the collagen fibers, eventually replaces most of the collagen, and occasionally results in formation of small cystic spaces. The pathogenesis of focal mucinosis is similar to that of myxoid cysts of the fingers and toes, and minor variations may be related to the anatomical differences of the involved sites. Similarities to and differences from other cutaneous mucinoses and myxomas are discussed. The lesions did not recur after simple surgical excision, and this appears to be the treatment of choice.

Author Affiliations
PHILADELPHIA

From the Skin and Cancer Hospital of Philadelphia, Department of Dermatology, Temple University School of Medicine, Philadelphia, and the Armed Forces Institute of Pathology, Washington, DC.

Footnotes
Accepted for publication Sept 1, 1965.

Read before the section on Dermatology at the 114th Annual Meeting of the American Medical Association, New York, June 22, 1965.

Reprint requests to Skin and Cancer Hospital, 3322 N Broad St, Philadelphia, Pa 19140 (Dr. Johnson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Multiple Translucent Papules on the Chest--Diagnosis
Arch Dermatol 2004;140:1531-1536.
FULL TEXT  

Large subcutaneous nodules in lower limbs following thyroiditis
Kakar and Byotra
Postgrad. Med. J. 1999;75:239-241.
FULL TEXT  

Superficial Hemosiderotic Angiomyxoma
Trotter et al.
INT J SURG PATHOL 1996;4:83-85.
ABSTRACT  

A Corrugated Plaque on the Abdominal Wall
Requena et al.
Arch Dermatol 1990;126:1641-1642.
ABSTRACT  

Acral Persistent Papular Mucinosis: A New Entity
Rongioletti and Rebora
Arch Dermatol 1986;122:1237-1239.
ABSTRACT  

Cutaneous Myxomas: A Major Component of the Complex of Myxomas, Spotty Pigmentation, and Endocrine Overactivity
Carney et al.
Arch Dermatol 1986;122:790-798.
ABSTRACT  

Focal Scleral Mucinosis
Margo
Arch Ophthalmol 1986;104:806-807.
ABSTRACT  

Conjunctival Myxoma: A Clinicopathologic Study of Four Cases and a Review of the Literature
Patrinely and Green
Arch Ophthalmol 1983;101:1416-1420.
ABSTRACT  

Cutaneous Mucinosis of Infancy: A Congenital and Linear Variant
McGrae
Arch Dermatol 1983;119:272-273.
ABSTRACT  

Multiple Cutaneous Focal Mucinoses with Hypothyroidism
JAKUBOVIC et al.
ANN INTERN MED 1982;96:56-58.
ABSTRACT  

Cutaneous Mucinosis of Infancy
Lum
Arch Dermatol 1980;116:198-200.
ABSTRACT  

Secondary Cutaneous Mucinosis With Systemic Lupus Erythematosus: A Case Presentation and Review of the Literature
Gammon et al.
Arch Dermatol 1978;114:432-435.
ABSTRACT  

Malignant Atrophic Papulosis of Degos: Report of a Patient Who Failed to Respond to Fibrinolytic Therapy
Howsden et al.
Arch Dermatol 1976;112:1582-1588.
ABSTRACT  

Lichen Myxedematosus: A Dermal Infiltrative Disorder Responsive to Cyclophosphamide Therapy
Howsden et al.
Arch Dermatol 1975;111:1325-1330.
ABSTRACT  

Mucinous (Adenocystic) Carcinoma of the Skin
Mendoza and Helwig
Arch Dermatol 1971;103:68-78.
ABSTRACT  

Pachydermoperiostosis: Touraine-Solente-Gole Syndrome
HAMBRICK and CARTER
Arch Dermatol 1966;94:594-608.
ABSTRACT