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Investigation of Porphyrins and Blood Lipids

LEO ZIPRKOWSKI, MD; ARYEH SZEINBERG, PhD; MOSHE CRISPIN, MSc; ANATOL KRAKOWSKI, MD; JACOB ZAIDMAN, MSc

Arch Dermatol. 1966;93(1):21-27.

Abstract
The known effect of griseofulvin on the metabolism of porphyrins in animals was confirmed in a case of porphyria cutanea tarda in an elderly man, to whom griseofulvin was given purposely to study the result—significant increases of fecal coproporphyrins were observed, more marked than in normal individuals. The increase of blood coproporphyrin was comparable to that observed in the normal controls. The level of blood lipids was unaffected by griseofulvin administration.

Author Affiliations
TEL HASHOMER, ISRAEL

From the Department of Dermatology (Drs. Ziprokowski and Krakowski) and the the Department of Chemical Pathology (Dr. Szeinberg; Mr. Crispin; and Mr. Zaidman), Government Hospital Tel-Hashomer, Tel Aviv University Medical School.

Footnotes
Accepted for publication Oct 6, 1965.

Reprint requests to Government Hospital, Tel-Hashomer, Israel (Dr. Szeinberg).

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