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A Variant of Lichen Myxedematosus

EARL J. RUDNER, MD; AMIR MEHREGAN, MD; HERMANN PINKUS, MD

Arch Dermatol. 1966;93(1):3-12.

Abstract
Two patients with typical skin lesions of scleromyxedema (lichen myxedematosus) are described. The disorder is characterized by proliferation of fibroblasts and excessive deposition of acid mucopolysaccharides in the dermis. Quantitative elevated levels of acid mucopolysaccharides were demonstrated in the serum and skin of one patient. Each patient presented a clinical course ending in fatality, consisting of coronary atherosclerosis and bizarre central nervous system symptoms. Acid mucopolysaccharides were not demonstrated by histochemical examination of other organs at autopsy. A review of other similar cases indicates that abnormalities of serum proteins, bone marrow, and other systemic symptoms may rarely accompany this condition. It is postulated that scleromyxedema may be a disorder of altered fibroblastmucopolysaccharide balance and represent a special group under the lichen myxedematous conditions.

Author Affiliations
DETROIT

From the Department of Dermatology, Wayne State University College of Medicine, and Detroit Receiving Hospital, Detroit.

Footnotes
Accepted for publication Aug 23, 1965.

Reprint requests to 1400 Chrysler Expwy, Detroit, Mich 48207 (Dr. Rudner).

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