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Studies of Host-Parasite Relationships

VICTOR D. NEWCOMER, MD; JOSEPH W. LANDAU, MD; ROBERT LEHMAN, MD; NINA DABROWA, MA; AIKO FUJIWARA, MD

Arch Dermatol. 1966;93(2):149-161.

Abstract
Candida granuloma, an unusual infection produced by Candida albicans, usually begins in early childhood and prior to the use of amphotericin B pursued an invariably chronic and progressive course. Immunologic abnormalities in the host have frequently been considered to be the essential predisposing factor for the development of this syndrome. This paper presents the results of studies of several parameters associated with host-parasite relationships in a patient with Candida granuloma. Special research and routine studies did not disclose any specific property of the fungus or defect in the defense mechanisms of the patient to account for the development of this disease. The concept of specific immunologic unresponsiveness is proposed to explain the patient's extreme susceptibility to the development of infection with C albicans.

Author Affiliations
LOS ANGELES

From the Department of Medicine, Division of Dermatology, University of California, The Center for the Health Sciences and the Medical Service, Veterans Administration Center, General Medical and Surgical Hospital.

Footnotes
Accepted for publication June 4, 1965.

Read before the American Dermatological Association, Inc., Boca Raton, Fla, February 1965.

Reprint requests to Department of Medicine, Division of Dermatology, University of California, The Center for the Health Sciences, Los Angeles 90024 (Dr. Newcomer).

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