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Genetic Evidence for a Unitary Origin

JAMES H. HERNDON, JR., MD; JEAN D. WILSON, MD

Arch Dermatol. 1966;93(3):305-310.

Abstract
Twelve members of a single family were found to exhibit a disorder of keratinization. Seven of these persons had findings characteristic of Ackrokeratosis Verruciformis (Hopf), one member or possibly two had Darier's disease, and three of the family had minor disturbances of keratinization. It was proposed that these disorders represent variable manifestations of a single underlying genetic defect in keratin formation.

Author Affiliations
DALLAS

From the Department of Internal Medicine, The University of Texas Southwestern Medical School and Parkland Memorial Hospital, Dallas.

Footnotes
Accepted for publication Dec 14, 1965.

Reprint requests to Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas 75235 (Dr. Wilson).

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