This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Treatment With Folic Acid Antagonists

JACK BROWN, MD; HAROLD O. PERRY, MD

Arch Dermatol. 1966;94(5):636-638.

Abstract
Four patients with pityriasis rubra pilaris were treated with the oral form of folic acid antagonists (aminopterin and methotrexate) for an average duration of 12 months. Marked clinical improvement was noted in all four patients. Two patients have discontinued therapy for periods of 24 and 7 months and have not had a recurrence of their disease.

The pharmacology of folic acid antagonists and the rationale for their use in the treatment of pityriasis rubra pilaris are briefly discussed.

Author Affiliations
ROCHESTER, MINN

From the Section of Dermatology, Mayo Clinic and Mayo Foundation (Dr. Perry), and Mayo Graduate School of Medicine, University of Minnesota (Dr. Brown), Rochester.

Footnotes
Accepted for publication Aug 24, 1966.

Reprint requests to 200 First St SW, Rochester, Minn 55901 (Dr. Brown).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pityriasis Rubra Pilaris Responding to Aminonicotinamide
Binnick
Arch Dermatol 1978;114:1348-1349.
ABSTRACT  

Immunosuppressive and Cytotoxic Drugs in Dermatology
Dantzig
Arch Dermatol 1974;110:393-406.
ABSTRACT  

Pityriasis Rubra Pilaris: Prolonged Treatment With Methotrexate
Knowles and Chernosky
Arch Dermatol 1970;102:603-612.
ABSTRACT  

Pityriasis Rubra Pilaris: A Follow-up Study of 57 Patients
Davidson et al.
Arch Dermatol 1969;100:175-178.
ABSTRACT  

Pityriasis Rubra Pilaris: Report of a Case and Analysis of the Literature
Gross et al.
Arch Dermatol 1969;99:710-716.
ABSTRACT