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Lack of Physiologic and Therapeutic Significance

RICHARD D. CARR, MD; WILLIAM M. TARNOWSKI, MD

Arch Dermatol. 1966;94(5):639-642.

Abstract
Percutaneous absorption of topically applied triamcinolone acetonide ointment under polyethylene film occlusive wraps caused endogenous adrenocortical suppression in two patients with generalized atopic dermatitis, one normal patient, and one patient with generalized mild dermatitis due to the occlusive dressings. Continued occlusive therapy without steroid ointment did not prolong the adrenal suppression. Thus the corticosteroid reservoir in the stratum corneum was not sufficient to maintain enough percutaneous steroid absorption to suppress the pituitaryadrenal axis. Lack of clinical effectiveness plus frequent development of a low-grade irritant dermatitis in areas where plastic wraps without corticoids were applied make us doubt that the corticosteroid reservoir of Vickers has therapeutic value.

Author Affiliations
COLUMBUS, OHIO

From the Division of Dermatology of the Department of Medicine of the Ohio State University College of Medicine, Columbus.

Footnotes
Accepted for publication Aug 8, 1966.

Reprint requests to 320 W Tenth Ave, Columbus, Ohio 43210 (Dr. Carr).

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