This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (48)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

II. Effect of Certain Bases and Pretreatments

ROBERT J. FELDMANN, MD; HOWARD I. MAIBACH, MD

Arch Dermatol. 1966;94(5):649-651.

Abstract
Single doses of radiolabeled¹⁴C hydrocortisone and testosterone were applied to the human forearm; rates and quantities of¹⁴C penetration were determined by assay of¹⁴C urine for five days. Dimethyl sulfoxide (DMSO) and dimethyl formamide (DMF) increased penetration of both steroids threefold to fourfold. Mineral oil was without obvious effect; propylene glycol (PG) and dimethyl acetamide (DMAC) decreased the penetration of hydrocortisone and moderately increased that of testosterone.

Author Affiliations
SAN FRANCISCO

From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco.

Footnotes
Accepted for publication Aug 16, 1966.

Reprint requests to Division of Dermatology, University of California, San Francisco Medical Center, San Francisco 94122 (Dr. Maibach).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Percutaneous Penetration of Hydrocortisone With Urea
Feldmann and Maibach
Arch Dermatol 1974;109:58-59.
ABSTRACT  

Bioassay System for Formulations of Topically Applied Glucocorticosteroids
Stoughton
Arch Dermatol 1972;106:825-827.
ABSTRACT