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The Syndrome of Telangiectatic Erythema and Growth Retardation

JOSEPH W. LANDAU, MD; M. S. SASAKI, DSc; VICTOR D. NEWCOMER, MD; AMOS NORMAN, PhD

Arch Dermatol. 1966;94(6):687-694.

Abstract
Bloom's syndrome is a genodermatosis characterized by a telangiectatic erythema of the face beginning in infancy, sensitivity to sunlight, small stature, and a low birth weight after a full-term gestation. A structural chromosome abnormality and an increased incidence of leukemia are associated. A classical example of this syndrome is presented in a patient who also exhibited low yA and M levels in the serum. Bloom's syndrome is compared with four other syndromes that have some similarity to it: Rothmund-Thomson syndrome, Cockayne's syndrome, ataxiatelangiectasia, and dyskeratosis congenita. These syndromes may be unrelated or may represent variants of the same underlying condition.

Author Affiliations
LOS ANGELES

From the Department of Medicine, Division of Dermatology (Drs. Landau and Newcomer) and the Department of Radiology (Drs. Sasaki and Norman), University of California at Los Angeles School of Medicine, Los Angeles.

Footnotes
Accepted for publication Sept 6, 1966.

Reprint requests to Division of Dermatology, University of California School of Medicine, Los Angeles 90024 (Dr. Landau).

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