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A Variant of Klinefelter's Syndrome

WILLARD C. PETERSON, JR., MD; ROBERT J. GORLIN, MD; FREDERIC PEAGLER, MD; HEINZ BRUHL, MD

Arch Dermatol. 1966;94(6):695-698.

Abstract
Five individuals with a variant of Klinefelter's (XXYY) syndrome are presented. The characteristics of the syndrome are discussed, including those signs of interest to dermatology. They include variations in body hair, lack of acne at adolescence, multiple cutaneous angiomas, acrocyanosis, and peripheral vascular disease producing the early onset of stasis dermatitis. The stasis change resembles that found in patients of normal genotype both clinically and histologically. The various effects of androgens and estrogens on peripheral vasculature are discussed.

Author Affiliations
MINNEAPOLIS

From the Divisions of Dermatology and Oral Pathology, University of Minnesota, Minneapolis (Drs. Peterson and Gorlin); the Department of Oral Surgery, Howard University, Washington, DC (Dr. Peagler); and the Department of Pediatrics, Minnesota State School, Faribault.

Footnotes
Accepted for publication Sept 19, 1966.

Reprint requests to University of Minnesota, Minneapolis 55455 (Dr. Peterson).

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