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II. Using Artificial Light Sources

W. MITCHELL SAMS, JR., MD

Arch Dermatol. 1966;94(6):773-777.

Abstract
Phototoxicity to chlorpromazine has been demonstrated in guinea pigs. This phototoxic reaction, characterized by erythema and necrosis of the ears, is produced regularly and easily. The source of ultraviolet was either a bank of fluorescent ultraviolet lamps or a high-pressure mercury vapor lamp. Phototoxicity was demonstrable only when a tough transparent plastic (Mylar) was interposed between the light source and the experimental animals. Without the plastic, the phototoxic response was masked by the normal erythema.

It was not possible to consistently demonstrate phototoxicity to demethylchlortetracycline or chlorothiazide using these methods.

Author Affiliations
SAN FRANCISCO

From the Dermatology Research Section, Research and Development Service, Letterman General Hospital, San Francisco. Dr. Sams is now at the Mayo Clinic in Rochester, Minn.

Footnotes
Accepted for publication July 18,1966.

Reprint requests to Director, Dermatology Research Section, Letterman General Hospital, San Francisco 94129.

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