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BERNARD I. GORDON, MD; HOWARD I. MAIBACH, MD

Arch Dermatol. 1966;94(6):778-781.

Abstract
Acetylcholine- and methacholine-induced sweating was quantitated over time. Acetylcholine produces sweat more rapidly and more evanescently than methacholine. Methacholine-induced sweating is delayed initially but is prolonged. Amounts of sweat are not always drug-concentration dependent.

Sex differences were quantitated. In agreement with previous studies, men consistently produced more sweat than women.

Repeated methacholine injections failed to produce a depression in sweating (hidromeiosis). To the contrary, increased amounts of sweat were noted (sweat-gland training).

Author Affiliations
SAN FRANCISCO

From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco.

Footnotes
Accepted for publication July 26, 1966.

Reprint requests to University of California School of Medicine, San Francisco 94122 (Dr. Maibach).

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