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REES B. REES, MD; JAMES H. BENNETT, MD; HOWARD I. MAIBACH, MD; HARRY L. ARNOLD, MD

Arch Dermatol. 1967;95(1):2-11.

Abstract
Methotrexate is used for psoriasis by the majority of teaching services of dermatology in the United States. Three modes of administration were compared: small daily doses by mouth in interrupted schedules, single large weekly oral doses, and parenteral doses. All methods were effective and had toxicity, but the parenteral route showed the greatest toxicity. The drug is contraindicated in pregnancy, hematological disorders, peptic ulceration, and liver disease. Chromosomal breaks have been reported with greater frequency than normal. Renal clearance is vital. The drug should be considered only for very severe forms of psoriasis.

Author Affiliations
SAN FRANCISCO; HONOLULU

From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco, (Drs. Rees, Bennett, and Maibach) and the Department of Dermatology, Straub Clinic, Honolulu (Dr. Arnold).

Footnotes
Accepted for publication Aug 10, 1966.

Read before the 86th Annual Meeting of the American Dermatological Association, Inc., Hot Springs, Va, April 18, 1966.

Reprint requests to Division of Dermatology, University of California School of Medicine, San Francisco, Calif 94108 (Dr. Rees).

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