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W. Stacy Miller, MD; Frank R. Ruderman, BS; J. Graham Smith, Jr., MD

Arch Dermatol. 1967;95(4):357-358.

Abstract
In a double-blind crossover study orally administered aspirin buffered with magnesium aluminum hydroxide significantly reduced ultraviolet light-induced erythema in ten adult male subjects when compared with magnesium aluminum hydroxide used as a placebo. This effect was most noticeable at four and six hours postirradiation but could be detected at 24 hours. Of the four subjects who complained of itching, aspirin relieved this symptom. The amount of aspirin taken (3.6 gm per day) was within the usual therapeutic dose.

The mechanism of this effect of aspirin is not known. A possible mechanism of action could be stabilizing lysosomes and the inhibition of kinins or enzymes.

Author Affiliations
Durham, NC

From the Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Jan 20, 1967.

Read before the American Academy of Dermatology, Bal Harbour, Fla, Dec 7, 1966.

Reprint requests to Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham, NC 27706 (Dr. Smith).

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