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Experiments of Nature

Milton Orkin, MD

Arch Dermatol. 1967;95(5):524-531.

Abstract
Study of spontaneous disorders in lower animals provides information more relevant to human disease than does laboratory-induced disease. A number of fascinating spontaneous models for human disease are delineated, viz, systemic lupus erythematosus in dogs and mice, porphyria in cows and pigs, atopic disease in dogs, Chediak-Higashi syndrome in the mink and partial albino cattle, cyclic neutropenia in the dog, and balding in a primate other than man. Study of animals should bring forth basic information affording clearer concepts of pathogenesis, as well as a more meaningful approach to therapeutic trials, of these and related diseases in many species.

Author Affiliations
Minneapolis

From the Division of Dermatology, University of Minnesota Medical School, Minneapolis.

Footnotes
Accepted for publication Dec 27, 1966.

Read in part before the Pacific Dermatologic Association, Palm Springs, Calif, Oct 29, 1966.

Reprint requests to Division of Dermatology, University of Minnesota Medical School, Minneapolis 55455 (Dr. Orkin).

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