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John H. Epstein, MD; Richard K. Winkelmann, MD

Arch Dermatol. 1967;95(5):532-536.

Abstract
The in vivo response of human skin to erythemogenic ultraviolet rays was evaluated in six normal and three atopic subjects utilizing a carbon-arc source with therapeutic C carbons and dermal perfusion techniques. Kinin and histamine bioassays of the perfusion fluid revealed no evidence of histamine release. In contrast, kinins appeared within 21 minutes after completion of the exposures in the six normal subjects, Initiation of the perfusions 3 hours and 24 hours after the ultraviolet exposure showed no kinin formation. No kinins were detected in atopic subjects despite development of normal delayed erythema reactions.

Thus, the kinin response was transitory in nature, and was not responsible for the production or persistence of the delayed sunburn erythema.

Author Affiliations
San Francisco

From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco (Dr. Epstein) and the Section of Dermatology, Mayo Clinic, Rochester, Minn (Dr. Winkelmann).

Footnotes
Accepted for publication Jan 27, 1967.

Reprint requests to Division of Dermatology, University of California San Francisco Medical Center, San Francisco 94122 (Dr. Epstein).

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