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  Vol. 95 No. 6, June 1967 TABLE OF CONTENTS
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Inability to Induce Keratinization in Basal Cell Tumors

Wounding and Application of Resin Podophyllum

Donald S. Waldorf, MD; Eugene J. Van Scott, MD

Arch Dermatol. 1967;95(6):576-582.


Abstract

Basal cell tumors were superficially wounded or exposed to 24-hour occlusive applications of 0.5% resin podophyllum in alcoholic solution. These stimuli did not induce the tumor cells to participate in the healing process nor to show any detectable sign of keratinization. These observations support the hypothesis that basal cell tumors are derived from cutaneous epithelial cells which have lost the capacity of keratinization.



Author Affiliations

New York

From the Dermatology Branch, National Cancer Institute, National Institutes of Health, US Public Health Service, Bethesda, Md. Dr. Waldorf is presently at the Department of Dermatology, New York University School of Medicine, New York.


Footnotes

Accepted for publication Feb 27, 1967.

Reprint requests to Department of Dermatology, New York University School of Medicine, New York 10016 (Dr. Waldorf).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Nodular Basal Cell Carcinoma In Vivo vs In Vitro: Establishment of Pure Cell Cultures, Cytomorphologic Characteristics, Ultrastructure, Immunophenotype, Biosynthetic Activities, and Generation of Antisera
Grando et al.
Arch Dermatol 1996;132:1185-1193.
ABSTRACT  





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