This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

I. The Mechanism of Action of Hydroxychloroquine

R. S. Lester, MD; T. K. Burnham, MB, BS (London); G. Fine, MD; K. Murray, MD

Arch Dermatol. 1967;96(1):1-10.

Abstract
Sixty-four patients were light tested to determine the relationships between systemic and discoid lupus erythematosus (SLE, DLE) and polymorphous light eruption (PMLE) in immunopathologic responses to light and the mechanism of action of antimalarial drugs. The effects of intradermal hydroxychloroquine sulfate (Plaquenil), methylprednisolone sodium succinate (Solu-Medrol), methotrexate, and saline, and topical applications of hydroxychloroquine and saline on cutaneous responses to ultraviolet light were studied in a smaller group. There was significant diminution of delayed erythema and blocking of the reproduced eruptions almost only at the intradermal hydroxychloroquine site in five (SLE, 1; DLE, 2; and PMLE, 2) out of seven positive lighttest reactors. The incidence of positive light tests was higher in the antinuclear factor (ANF) tests (11.1%) suggesting a more active disease state in the ANF positive PMLE patients. Antimalarial drugs may conceivably act by interfering with complement activity at the local tissue level in SLE, DLE, and PMLE or by deoxyribonucleic acid binding.

Author Affiliations
Detroit

From the departments of dermatology (Drs. Lester, Burnham, and Murray) and pathology (Dr. Fine), Henry Ford Hospital, Detroit.

Footnotes
Accepted for publication Jan 20, 1967.

Reprint requests to Department of Dermatology, Henry Ford Hospital, Detroit 48202 (Dr. Burnham).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit
Wozniacka et al.
Lupus 2002;11:71-81.
ABSTRACT  

Phototesting and photoprotection in LE
Walchner et al.
Lupus 1997;6:167-174.
ABSTRACT  

Photoimmunology
Morison et al.
Arch Dermatol 1979;115:350-355.
ABSTRACT  

Action Spectra of Lupus Erythematosus and Experimental Immunofluorescence
Cripps and Rankin
Arch Dermatol 1973;107:563-567.
ABSTRACT  

Lupus Erythematosus
Tuffanelli
Arch Dermatol 1972;106:553-566.
ABSTRACT  

The Immunofluorescent "Band" Test for Lupus Erythematosus: III. Employing Clinically Normal Skin
Burnham and Fine
Arch Dermatol 1971;103:24-32.
ABSTRACT  

Immunofluorescent "Band" Test for Lupus Erythematosus: II. Employing Skin Lesions
Burnham et al.
Arch Dermatol 1970;102:42-50.
ABSTRACT  

Polymorphous Light Eruption and Lupus Erythematosus: Differential Diagnosis by Fluorescent Microscopy
Fisher et al.
Arch Dermatol 1970;101:458-461.
ABSTRACT  

Cutaneous Lesions of Lupus Erythematosus Induced by Monochromatic Light
Freeman et al.
Arch Dermatol 1969;100:677-682.
ABSTRACT