This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Recent Problems

Hans Selye, MD, PhD, FRCS, DSc

Arch Dermatol. 1967;96(4):367-371.

Abstract
Identical cutaneous lesions can be elicited by several combinations of the following pathogens that in themselves are inactive and essentially different: (1) "sensitizers," which induce a latent predisposition for a specific reaction form (eg, inflammation, calcification, thrombosis and hemorrhage, necrosis); and (2) "challengers," which unmask this predisposition by making the disease manifest and determining its location.

It may be significant that in all the disease models mentioned in this review, mast-cell dischargers and mast-cell products act as potent elicitors for diverse skin reactions; it therefore appears justified to conclude that close relationships exist between mast cells and tissue resistance to numerous pathogens.

Author Affiliations
Montreal

From the Institute de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal.

Footnotes
Read before the Symposium on Skin Diseases Common to Man and Animals, Palm Springs, Calif, Nov 2, 1966.

Reprint requests to Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, CP 6128, Montreal (Dr. Selye).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?