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Isoenzymes of the Human Epidermis
Kenneth M. Halprin, MD;
Akira Ohkawara, MD;
Kiyomi Fukui, MD
Arch Dermatol. 1968;98(3):299-309.
Abstract
Further studies designed to clarify the isoenzymic forms of glycolytic enzymes within the human epidermis have revealed one protein (enzyme) with hexokinase activity, three with phosphoglucomutase activity, one with phosphohexose isomerase activity, five with aldolase activity, one with phosphoglycerate mutase activity, two with enolase activity, one with pyruvate kinase activity, and two with phosphorylase activity. The single form of hexokinase corresponds to type I of liver which is not insulin sensitive. The single form of pyruvate kinase corresponds to type III of liver which is not inducible by insulin. Both phosphorylase a and b which probably correspond to muscle type phosphorylase rather than liver are present in epidermis. In addition, a phosphorylase kinase capable of converting b to a can be demonstrated.
Author Affiliations
Portland, Ore
From the Department of Medicine, Division of Dermatology, University of Oregon Medical School, Portland, Oregon. Drs. Halprin and Fukui are now at the Veterans Administration Hospital, Miami, Fla, and Dr. Ohkawara is now at the University of Hakkaido, Hakkaido, Sapporo, Japan.
Footnotes
Accepted for publication May 6, 1968.
Reprint requests to 1201 NW 16th St, Miami, Fla 33136 (Dr. Halprin).
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