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Epidermodysplasia Verruciformis, Vacuolar Degeneration of the Epidermis

Chalmers E. Cornelius III, MD; Joseph A. Witkowski, MD; Margaret Gray Wood, MD

Arch Dermatol. 1968;98(4):377-384.

Abstract
The human papova virus, human wart virus, produces lesions of many forms. A case is reported of atypical viral verruca. The lesions were erythematous smooth polygonal slightly elevated dime-size papules on the midback in a middle aged white man. When pressure was applied to the lesions a Nikolsky-like separation occurred.

Histological examination of the lesions showed a widespread distribution of vacuolated cells in the malpighian layer, similar to that seen in epidermodysplasia verruciformis. Feulgen positive intranuclear inclusion bodies were noted in the granular layer. Electron microscopic examination of the granular layer revealed intranuclear particles in a semicrystalloid arrangement of the size of human papova virus.

Author Affiliations
Philadelphia

From the Departments of Dermatology, University of Pennsylvania School of Medicine and Veterans Administration Hospital, Philadelphia.

Footnotes
Accepted for publication April 25, 1968.

Reprint requests to Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia 19104 (Dr. Cornelius).

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