This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

R. E. Billingham, DSc; J. Wayne Streilein, MD

Arch Dermatol. 1968;98(5):528-539.

Abstract
If immunologically competent cells are injected into infant or adult animals under conditions that exempt the grafted cells from rejection and at the same time result in their being confronted by strong alien host transplantation isoantigens, graftversus-host reactions occur. These are responsible for the so-called homologous or transplantation diseases. An exfoliative dermatitis and other abnormalities of the skin are frequently the first overt symptoms of these diseases.

Following the intracutaneous injection of adult (MHA X CB)F₁ hybrid hamsters with suspensions of parental strain lymphoid cells, local inflammatory reactions develop. About a week later there is generalized erythroderma and a positive Nikolsky sign involving the entire integument. Affected animals usually succumb to this acute homologous disease within two or three weeks of inoculation.

An account is presented of these skin lesions, which closely resemble those of the clinical syndrome toxic epidermal necrolysis, and of an experimental analysis of their etiology.

Author Affiliations
Philadelphia

From the Department of Medical Genetics, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication May 23, 1968.

Reprint request to Department of Medical Genetics, University of Pennsylvania, Philadelphia 19104 (Dr. Billingham).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Severe Adverse Cutaneous Reactions to Drugs
Roujeau and Stern
NEJM 1994;331:1272-1285.
FULL TEXT  

T-Cell Subsets in Drug-Induced Toxic Epidermal Necrolysis: Possible Pathogenic Mechanism Induced by CD8-Positive T Cells
Miyauchi et al.
Arch Dermatol 1991;127:851-855.
ABSTRACT  

Toxic Epidermal Necrolysis: Unmuddying the Waters
Goldstein et al.
Arch Dermatol 1987;123:1153-1156.
ABSTRACT  

Genetic Susceptibility to Toxic Epidermal Necrolysis
Roujeau et al.
Arch Dermatol 1987;123:1171-1173.
ABSTRACT  

Lymphocyte Subsets and Langerhans' Cells in Toxic Epidermal Necrolysis: Report of a Case
Merot et al.
Arch Dermatol 1986;122:455-458.
ABSTRACT  

Delayed Hypersensitivity in Ampicillin-Induced Toxic Epidermal Necrolysis
Tagami et al.
Arch Dermatol 1983;119:910-913.
ABSTRACT  

Toxic Epidermal Necrolysis From Graft-vs-Host Disease: Occurrence in a Patient With Thymic Hypoplasia
McCarty et al.
Arch Pediatr Adolesc Med 1978;132:282-284.
ABSTRACT  

Scleroderma-like Changes in Chronic Graft vs Host Disease
Spielvogel et al.
Arch Dermatol 1977;113:1424-1428.
ABSTRACT  

Graft-vs-Host Reaction
Grogan et al.
Arch Dermatol 1977;113:806-812.
ABSTRACT  

Staphylococcal Scalded Skin Syndrome: Clinical Features, Pathogenesis, and Recent Microbiological and Biochemical Developments
Elias et al.
Arch Dermatol 1977;113:207-219.
ABSTRACT  

Thiabendazole-Induced Toxic Epidermal Necrolysis
Robinson and Samorodin
Arch Dermatol 1976;112:1757-1760.
ABSTRACT  

Graft Versus Host Reaction: An Ultrastructural Study
De Dobbeleer et al.
Arch Dermatol 1975;111:1597-1602.
ABSTRACT  

Toxic Epidermal Necrolysis in a Patient With Graft-vs-Host Reaction
Peck et al.
Arch Dermatol 1972;105:561-569.
ABSTRACT