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False-Positive Reactions for SyphilisSerological Abnormalities in Relatives of Chronic Reactors
Denny L. Tuffanelli, MD
Arch Dermatol. 1968;98(6):606-611.
Abstract
One-hundred and three probands with chronic false-positive (CFP) seroreactions for syphilis and 199 relatives were studied clinically and serologically. The probands were characterized by an increased incidence of antinuclear-antibodies, rheumatoid factors, hypergammaglobulinemia, and elevated IgM levels. There was no increased incidence of clinical disease in the relatives. They were found to have a higher incidence of antinuclear factor (16.5%), rheumatoid factor (14.2%), and hypergammaglobulinemia (16.9%). Serum immunoglobulin studies revealed the relatives to have a statistically significant elevation of IgG and depression of IgM.
A genetic background of an inherited defect in immunoglobulin control mechanisms is implied in patients with CFP seroreactions for syphilis. However, if familial aggregation exists, it operates at a low level and does not correspond to a simple genetic pattern.
Author Affiliations
San Francisco
From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco.
Footnotes
Accepted for publication August 21, 1968.
Read before the 117th Annual Convention of the American Medical Association, Section on Venereal Diseases, San Francisco, June 17-20, 1968.
Reprint requests to Division of Dermatology, University of California San Francisco Medical Center, San Francisco, 94122 (Dr. Tuffanelli).
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Dermatologic Advances: 1968-1969
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Arch Dermatol 1970;101:12-20.
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