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  Vol. 99 No. 1, January 1969 TABLE OF CONTENTS
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Bullous Pemphigoid Associated With Systemic Lupus Erythematosus

Robert E. Jordon, MD; Sigfrid A. Muller, MD; William L. Hale, MA; Ernst H. Beutner, PhD

Arch Dermatol. 1969;99(1):17-25.


Abstract

Three cases of bullous pemphigoid associated with systemic lupus erythematosus (SLE) are presented. Indirect immunofluorescent (IF) studies performed on sera from two of the patients revealed basement membrane zone antibodies characteristic of bullous pemphigoid and nuclear antibodies characteristic of SLE. Direct IF studies revealed in vivo bound {gamma}-globulin localized to the basement membrane zone in skin biopsy specimens from two of these patients. Pathologic observations of a third patient with bullous pemphigoid who died of SLE are also presented. This association with SLE adds further support to a possible auto-immune disturbance being operative in bullous pemphigold.



Author Affiliations

Rochester, Minn; Buffalo, NY

From the Mayo Clinic and Mayo Foundation, Section of Dermatology (Dr. Muller), the Mayo Graduate School of Medicine, University of Minnesota, Rochester (Dr. Jordon), and the State University of New York at Buffalo, Department of Microbiology (Mr. Hale and Dr. Beutner).


Footnotes

Accepted for publication Aug 29, 1968.

Reprint requests to Mayo Clinic, 200 First St, SW Rochester, Minn 55901 (Dr. Jordon).



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