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Cantharone (Seres Laboratories Inc, Santa Rosa, Calif) (active ingredient, cantharidin) is a potent vesicant used topically to treat verrucae vulgaris.¹ We recently encountered a patient who developed acute cellulitis and/or lymphangitis soon after topical application of Cantharone for eradication of plantar verrucae in an otherwise normal right leg. Although the patient's acute inflammation subsided, the peripheral swelling of her leg persisted and ultimately was documented by lymphangioscintigraphy to represent distal lymphatic obliteration (refractory lymphedema).

Report of a Case

A 39-year-old woman developed acute swelling, pain, blistering, and ulceration in an otherwise normal right foot and lower leg within a few hours after topical application of Cantharone (0.7% cantharidin) to 7 plantar verrucae (0.5-1.5 cm). Three days later the necrotic verrucae were excised while the patient was under local anesthesia and the base of each was treated with phenol and povidone-iodine (Betadine). Signs of acute inflammation subsided after several more days, but the patient's lower . . . [Full Text of this Article]

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