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In recent years it has become apparent that a minor proportion of malignant lymphomas express a natural killer (NK) cell phenotype defined by their reactivity with the CD56 antibody. A significant proportion of these lymphomas present with cutaneous infiltrations and seem to follow an aggressive clinical course.¹ We describe a patient with a cutaneous NK/T-cell lymphoma confined to the skin that showed an indolent course after local radiation therapy.

Report of a Case

A 21-year-old white woman presented with a 9.5x10.0-cm indurated, nontender, livid plaque on her left shin (Figure 1). The lesion had started as a small macule about 1 year before presentation and had slowly enlarged. A punch biopsy specimen showed a superficial and deep nodular infiltrate that extended into the subcutaneous fat (Figure 2). The epidermis and the papillary dermis were spared. The infiltrates were accentuated around dermal appendages and small blood vessels without frank . . . [Full Text of this Article]

Immunohistochemistry

Staging

Comment

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

CD56+ Lymphoma With Skin Involvement: Clinicopathologic Features and Classification
Arch Dermatol 2004;140:427-436.