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Intralesional Cisplatin for the Treatment of Cutaneous B-Cell Lymphoma
Werner Kempf, MD;
Reinhardn Dummer, MD;
Monika Hess Schmid, MD;
Tanja Fritz, MD;
Brunello Wüthrich, MD;
Guenter Burg, MD
Department of Dermatology, Zurich University Hospital, Zurich, Switzerland
Arch Dermatol. 1998;134:1343-1345.
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REPORT OF A CASE
A 56-year-old white woman presented with a solid erythematous nodule on her scalp that had developed 6 years earlier. She denied having a fever, losing weight, or sweating during the night. Her medical history was notable for epilepsy, which was adequately controlled with phenothiazine and chlorpromazine therapy. When a solitary nodule first appeared on the patient's head 6 years earlier, a biopsy specimen revealed nodular, dense B-cell infiltrates without blasts, nuclear atypias, or mitoses. Therefore, the lesion had been regarded clinically and histologically as a B-cell pseudolymphoma. The patient was subsequently treated with potent topical corticosteroid creams and local psoralenUV-A, but within 2 years the preexisting nodule became larger and 2 further nodules appeared despite the therapy. After topical chemotherapy using carbomustine and topical corticosteroids, the patient had a partial response . . . [Full Text of this Article]
THERAPEUTIC CHALLENGE
SOLUTION
COMMENT
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