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Xeroderma pigmentosum (XP) is a group of rare autosomal recessive conditions characterized by defective DNA repair. Exposure to UV light gives rise to cutaneous neoplasms already in childhood. Since the underlying genetic defect can not yet be corrected, prophylactic measures are of utmost importance. Meticulous protection from sunlight and early excision of skin tumors are mandatory. Surgical removal of sun-damaged skin may prevent the development of neoplasms. Excising and resurfacing the skin using grafts obtained from sun-protected regions has sometimes been performed.^1-4 Although the benefit of dermabrasion is well documented in patients with actinic damage,^5-6 there are only a few reports on this approach in XP.^{4, 7-9} We report a case of XP with a well-controlled long-term result obtained by dermabrasion and documented both clinically and histopathologically.

Report of a Case

A 59-year-old farmer with XP presented with a history of multiple precancerous skin lesions and cutaneous malignant neoplasms, such as squamous cell carcinoma and . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Total-Body Cutaneous Examination, Total-Body Photography, and Dermoscopy in the Care of a Patient With Xeroderma Pigmentosum and Multiple Melanomas
Green et al.
Arch Dermatol 2009;145:910-915.
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