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The descriptive term papular-purpuric gloves and socks syndrome (PPGSS) was coined by Harms et al¹ in 1990. Until now, 24 cases have been reported worldwide.^1-7 The patients show sharply marginated pruritic and/or painful erythema, edema, and small, flat papules in a symmetrical gloves-and-socks distribution with rapid development of petechial purpura. Prodromal signs (fatigue, anorexia, and sudden onset of fever) have been reported. The mucosal involvement consists of enanthema with small erosions and vesicles.

Papular-purpuric gloves and socks syndrome occurs in spring or summer and affects mainly young adults whose general health is good. The cause is unknown; however, in some cases various viruses, such as parvovirus B19, cytomegalovirus, measles virus, and Coxsackievirus B6 or the corresponding antibodies, have been detected in the skin or serum samples of the patients.^2-5

We describe a patient with typical symptoms of PPGSS related to an infection with human herpesvirus 6 (HHV-6).This combination has never . . . [Full Text of this Article]

Report of a Case


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