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Disseminated Blue Nevus: Abnormal Nevoblast Migration or Proliferation?
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The observation by Lycka et al1 of a patient with hundreds of nevi simulating neurofibromatosis (NF) has led those authors to hypothesize that this disease could be the consequence of an abnormal migration of nevoblasts. Herein we report a case similar to that of Lycka et al,1 in which the lesions were blue nevi. The close clinical features between NF and disseminated nevi or blue nevi raise the question of whether this syndrome results from a migration or a proliferation disorder of nevoblasts.
Report of a Case
A 29-year-old man from Senegal presented with skin nodules. The physical examination revealed a profusion of hundreds of dome-shaped, flesh-colored nodules distributed all over his body (Figure 1). A voluminous tumor measuring 40 cm was noted on the lower part of his back (Figure 2). Café au lait maculae, axillary freckling, and Lisch nodules were not found. No similar disorder was present in . . . [Full Text of this Article] Comment
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