This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In a recent issue of the ARCHIVES, McCormack et al¹ describe patients with superficial basal cell carcinoma (BCC) who had a significantly lower mean age at diagnosis than those with other subtypes and that 73.3% of superficial BCCs occur on the trunk.¹ We have investigated the role of polymorphism in various detoxifying enzymes on the risk of BCC. In particular, we have assessed the role of glutathione S-transferases (GST, GSTM1, and GSTT1).^2-4 These are good candidates for BCC pathogenesis since they play a role in the defense against UV-induced oxidative stress damage to the skin.^2-3

We recently assessed the implications of the truncal site of BCC as it relates to the risk of disease. We recruited, interviewed, genotyped, and followed up a cohort of patients with BCC. Patients with a truncal BCC at presentation were more likely to have multiple tumors (P=.002; odds ratio, 4.03)⁵ and were . . . [Full Text of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?