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In a recent issue of the ARCHIVES, McCormack et al¹ describe patients with superficial basal cell carcinoma (BCC) who had a significantly lower mean age at diagnosis than those with other subtypes and that 73.3% of superficial BCCs occur on the trunk.¹ We have investigated the role of polymorphism in various detoxifying enzymes on the risk of BCC. In particular, we have assessed the role of glutathione S-transferases (GST, GSTM1, and GSTT1).^2-4 These are good candidates for BCC pathogenesis since they play a role in the defense against UV-induced oxidative stress damage to the skin.^2-3

We recently assessed the implications of the truncal site of BCC as it relates to the risk of disease. We recruited, interviewed, genotyped, and followed up a cohort of patients with BCC. Patients with a truncal BCC at presentation were more likely to have multiple tumors (P=.002; odds ratio, 4.03)⁵ and were . . . [Full Text of this Article]